The results of the study devoted to studying the regenerative effect of an external agent based on Ginkgo double-lobed leaf extract (Ginkgo biloba L.) under conditions of thermal skin burns in laboratory animals are described. It has been found that the soft form of the preparation has a regulatory effect on the repair of skin tissues, manifesting itself in stopping inflammatory events and tightening the wound edges. Effectiveness of application of agent including Ginkgo extract of two-lobed (using basic forming components) and made in the form of cream was evaluated according to the following criteria: reduction of skin wound size, acceleration of time of recovery and epithelisation of burn skin wounds, reduction of treatment terms.
pharmacological activity, Ginkgo biloba, extract, biologically active substances
1. Azhikova, A. K. Ginkgo dvulopastnyy (Ginkgo biloba L.): perspektivy ispol'zovaniya v farmacii / A. K. Azhikova // Prikaspiyskiy vestnik mediciny i farmacii. - 2020. - T. 1. - № 1. - S. 6-13.
2. Burchinskiy, S. G. Vozmozhnosti preparatov ginkgo biloby v strategii farmakoterapii sosudistoy demencii / S. G. Burchinskiy // Mezhdunarodnyy nevrologicheskiy zhurnal. - 2012. - № 1. - S. 6-10.
3. Burchinskiy, S. G. Preparaty Ginkgo Biloba: po puti otkrytiy v klinicheskoy neyrofarmakologii / S. G. Burchinskiy // Mezhdunarodnyy nevrologicheskiy zhurnal. - 2016. - T. 4, № 82. - S. 83-87.
4. Vasil'ev, V. G. Identifikaciya terpenovyh laktonov i flavonoglikozidov v preparatah na osnove ekstrakta ginkgo biloba i novyy sposob polukolichestvennoy ocenki soderzhaniya flavonoglikozidov metodom spektroskopii YaMR 1N / V. G. Vasil'ev, A. S. Prokop'ev, G. A. Kalabin // Himiya rastitel'nogo syr'ya. - 2016. - № 3. - S. 85-93.
5. Vasil'ev, V. G. O neobhodimosti sovershenstvovaniya kontrolya bezopasnosti i kachestva ekstraktov iz list'ev ginkgo biloba / V. G. Vasil'ev, G. A. Kalabin, M. I. Bukasa, D. D. Rudachevskiy // Vestnik Rossiyskogo universiteta druzhby narodov. Seriya : Ekologiya i bezopasnost' zhiznedeyatel'nosti. - 2017. - T. 25, № 3. - S. 414-430.
6. Katunina, E. A. Ginkgo biloba : itogi poluvekovogo opyta primeneniya. Polimodal'nost' effektov ginkgo biloba : eksperimental'nye i klinicheskie issledovaniya / E. A. Katunina // Nevrologiya i revmatologiya. Prilozhenie k zhurnalu Consilium Medicum. - 2013. - № 2. - S. 53-57.
7. Kuznecova, S. M. Primenenie ekstrakta ginkgo biloba v sisteme reabilitacii bol'nyh, perenesshih insul't / S. M. Kuznecova, V. V. Kuznecov, D. V. Shul'zhenko // Mezhdunarodnyy nevrologicheskiy zhurnal. - 2016. - T. 5, № 83. - S. 111-114.
8. Litvinec, E. A. Ginkgo biloba: farmakologicheskie i lechebnye svoystva / E. A. Litvinec, O. R. Vintoniv // Zdorov'e muzhchiny. - Professional-Ivent (Kiev) - 2012. - T. 1, № 40. - S. 37.
9. Ponomarev, V. V. Effektivnost' ekstrakta Ginkgo biloba v lechenii legkogo i umerennogo kognitivnogo snizheniya sosudistogo geneza s pozicii dokazatel'noy mediciny / V. V. Ponomarev, E. V. Barabanova // Medicinskie novosti. - 2016. - T. 4, № 259. - S. 18-21.
10. Sidel'skaya, U. Yu. Sravnitel'naya harakteristika sposobov lecheniya zhivotnyh s termicheskimi ozhogami / U. Yu. Sidel'skaya // Mezhdunarodnyy nauchno-issledovatel'skiy zhurnal. - 2017. - № 8-2 (62). - S. 30-34.
11. Tirikov, I. V. Opyt klinicheskogo ispol'zovaniya ekstrakta Ginkgo biloba v kompleksnoy diabeticheskoy polineyropatii / I. V. Tirikov // Byulleten' Vostochno-Sibirskogo nauchnogo centra Sibirskogo otdeleniya Rossiyskoy akademii medicinskih nauk. - 2011. - T. 3, № 1. - S. 118-119.
12. Cui, Y. Effect of Ginkgo biloba leaf extract on cerebral cortex amino acid levels in cerebral ischemia model rats / Y. Cui, H. Wu, M. Liu, H. Yang, H. Qin, X. Liu // J. Tradit Chin Med. - 2018. - Vol. 38, № 5. - P. 676-684.
13. Eisvand, F. The effects of Ginkgo biloba on metabolic syndrome : A review / F. Eisvand, B. M. Razavi, H. Hosseinzadeh // Phytotherapy Research. - 2020. - Vol. 34, № 8. - P. 1798-1811. doi:https://doi.org/10.1002/ptr.6646.
14. Hao, F. Enhanced Neuroprotective Effects of Combination Therapy with Bone Marrow-Derived Mesenchymal Stem Cells and Ginkgo biloba Extract (EGb761) in a Rat Model of Experimental Autoimmune Encephalomyelitis / F. Hao, A. Li, H. Yu, M. Liu, Y. Wang, J. Liu, Z. Liang // Neuroimmunomodulation. - 2016. -Vol. 23, № 1. - P. 41-57. doi:https://doi.org/10.1159/000437429.
15. Hui, S. Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro / S. Hui, W. Fangyu // Biomed Pharmacother. - 2017. - № 85. - P. 592-600. doi:https://doi.org/10.1016/j.biopha.2016.11.068.
16. Ji, H. Ginkgo Biloba extract as an adjunctive treatment for ischemic stroke : A systematic review and meta-analysis of randomized clinical trials / H. Ji, X. Zhou, W. Wei, W. Wu, S. Yao // Medicine (Baltimore). - 2020. -Vol. 99, № 2. - e18568. doi:https://doi.org/10.1097/MD.0000000000018568.
17. Maleš, Ž. Application of medicinal plants in several dermatovenerological entities / Ž. Maleš, D. L. Drvar, I. Duka, K. Žužul // Acta Pharm. - 2019. - Vol. 69, № 4. - P. 525-531. doi:https://doi.org/10.2478/acph-2019-0045.
18. Polakova, K. A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris : result from a controlled randomized trial / K. Polakova, A. Fauger, M. Sayag, E. Jourdan // Clin Cosmet Investig Dermatol. - 2015. - Vol. 10, № 8. - P. 187-191. doi:https://doi.org/10.2147/CCID.S81691.
19. Sherif, I. O. Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury : New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression / I. O. Sherif, N. H. Al-Shaalan, D. Sabry // Biomolecules. - 2019. - Vol. 9, № 11. - P. 691. doi:https://doi.org/10.3390/biom9110691.
20. Zhang, L. Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model / L. Zhang, J. Liu, Y. Ge, M. Liu // Neuropsychiatr Dis Treat. - 2019. - № 15. - P. 3041-3050. doi:https://doi.org/10.2147/NDT.S229296.
21. Xiao, G. Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia-Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brain / G. Xiao, M. Lyu, Y. Wang, S. He, X. Liu, J. Ni, L. Li, G. Fan, J. Han, X. Gao, X. Wang, Y. Zhu // Front Pharmacol. - 2019. - № 10. - P. 735-735. doi:https://doi.org/10.3389/fphar.2019.00735.