Sudden anosmia and/or ageusia is one of the first and significant symptoms of COVID-19, which are manifested in good health and a successful course of the disease. Purpose: to analyze neurological disorders in COVID-19 and present the results of peripheral neuropathy of the olfactory nerve. We present the results of 39 (32 %) patients with olfactory dysfunction obtained among 121 patients with a positive RT-PCR test for COVID-19. The data was collected through a survey and questionnaire based on the AAO-HNS anosmia reporting tool. The majority of individuals (32 patients) did not have close contact with a positive case in the recent past. Most patients regained their sense of smell within 1-2 weeks of the onset of anosmia. To date, the mechanisms of anosmia in SARS-CoV-2 are not yet clear. It remains debatable whether anosmias are the result of nerve damage or inflammation of the olfactory nerves, which requires further research.
anosmia, loss of smell, dysgeusia, neuroinflammation, olfactory dysfunction, SARS-COV-2, COVID-19
1. Lechner M., Chandrasekharan D., Jumani K., Liu J., Gane S., Lund V.J., Philpott C., Jayaraj S. Anosmia as a presenting symptom of SARS-CoV-2 infection in healthcare workers - a systematic review of the literature, case series, and recommendations for clinical assessment and management // Rhinology. 2020. Vol. 58(4). P. 394-399.
2. Lechien J. R., Chiesa-Estomba C. M., De Siati D. R., Horoi M., Le Bon S. B., Rodriguez A. Olfactory and gustatory dysfunction as a clinical presentation of mild to moderate forms of the coronavirus disease (COVID-19): a multicenter European study // Eur. Arch. Otorhinolaryngol. 2020. Vol. 277, P. 2251-2261. doi:https://doi.org/10.1007/s00405-020-05965-1.
3. Al-Ani R.M., Acharya D. Prevalence of anosmia and ageusia in patients with COVID-19 at a Primary Health Center, Doha, Qatar // Indian Journal of Otolaryngology and Head & Neck Surgery. 2020. Vol. 19. P. 1-7.
4. ENTUK Loss of sense of smell as a marker of COVID-19 infection. 2020. URL: https://www.entuk.org/sites/default/files/files/Loss%20of%20sense%20of%20smell%20as%20marker%20of%20COVID.pdf.
5. American Academy of Otolaryngology-Head And Neck Surgery AAO-HNS: Anosmia, hyposmia, and dysgeusia symptoms of coronavirus disease. 2020. URL: https://www.entnet.org/content/aao-hns-anosmia-hyposmia-and-dysgeusia-symptoms-coronavirus-disease.
6. Pasquini J., Maremmani C., Salvadori S., Silani V., Ticozzi N. Testing olfactory dysfunction in acute and recovered COVID-19 patients: a single center study in Italy // Neurol Sci. 2021 June. Vol. 42(6). P. 2183-2189. doi:https://doi.org/10.1007/s10072-021-05200-7. Epub 2021 Mar 26. PMID: 33768438; PMCID: PMC7994059.
7. Krassowski M.ComplexUpset: Create Complex UpSet PlotsUsing ggplot2 Components. R Package Version 0.5.18. Zenodo. 2020. doi:https://doi.org/10.5281/zenodo.3700590
8. Kaye R., Chang C.W.D., Kazahaya K., Brereton J., Denneny J.C. COVID-19 anosmia reporting tool: initial findings // Otolaryngol Head Neck Surg. 2020. Vol. 163, P. 132-134.
9. Neto D. B., Fornazieri M. A., Dib C., Di Francesco R. C., Doty R. L., Voegels R. L. (2020). Chemosensory dysfunction in COVID-19: prevalences, recovery rates, and clinical associations on a large Brazilian Sample // Otolaryngology Head and Neck Surgery. 2020 September. Vol. 164(1), P. 68-70. doi:https://doi.org/10.1177/0194599820954825.
10. Giacomelli A., Pezzati L., Conti F., Bernacchia D., Siano M., Oreni L., Rusconi S., Gervasoni C., Ridolfo A.L., Rizzardini G., Antinori S. Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross-sectional study //Clin Infect Dis. 2020 Jul 28; Vol. 71(15). P. 889-890. doi:https://doi.org/10.1093/cid/ciaa330.
